*e toxicity of the aqueous extract of Origanum majorana was tested (5 and 10 g/kg) in albino mice. No symptoms of toxicity or\nmortality were observed. *e mice survived being active and healthy during all 14 days of observation. In addition, the weight\nmeasurement of the left and right kidneys, heart, and liver shows no significant difference between the control, 5 g/kg, and 10 g/kg.\nAll extracts (aqueous, petroleum ether, dichloromethane, ethyl acetate, methanolic, and depleted aqueous extracts) of Origanum\nmajorana tested against both types of cancer cells showed a more pronounced cytotoxic effect against breast cell line MDA-MB-\n231 than colon cells line HT-29 cells. *e most marked effect is that of the ethyl acetate extract with IC50 30.90 ± 1.39 and 50.11 ±\n1.44 ..... respectively. HPLC analysis of extracts from Origanum majorana showed that this plant contained polyphenols and\nflavonoids, which may be responsible for the biological activities found.
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